Numerical Simulations for ‘Autonomous Circadian Oscillators Intrinsic to Cell Membranes’
Description
This repository contains the computational models and simulation code for the membrane-based circadian oscillator described in:
**"Autonomous circadian oscillators intrinsic to cell membranes"**
Mauro A. Forlino, Oreste Piro, Monika Stengl & Martin E. Garcia
https://doi.org/10.21203/rs.3.rs-8788655/v1
Numerical models for "Autonomous circadian oscillators intrinsic to cell membranes" (Forlino, Piro, Stengl, Garcia). Computational models supporting the hypothesis that cell membranes can host autonomous post-translational feedback loops (PTFLs) capable of generating circadian (~24 h) oscillations independently of nuclear transcription-translation feedback. Two cell types are modeled: anucleate red blood cells, using a Goodwin-type feedback architecture, and neurons, using a Hodgkin-Huxley framework with coupled fast positive and delayed negative feedback. Both models produce self-sustained ~24 h oscillations without nuclear input.
